IO-108, a Fully Human Therapeutic Antibody Blocking the Myeloid Checkpoint LILRB2/ILT4, Promotes Innate and Adaptive Anti-Cancer Immunity in Preclinical Studies

Ma J. et al. The American Association for Cancer Research (AACR) Annual Meeting 2022. April 8–13, 2022

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A First-In-Human Phase 1 Trial of IO-108 as Monotherapy and in Combination with Pembrolizumab in Adult Patients with Advanced Relapsed or Refractory Solid Tumors

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LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2–cFLIP–NF-κB signaling axis